Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

被引：29
|
作者：
Zhu, Yujin [1 ,2 ]
Zhang, Yanjun [3 ]
Liu, Yi [1 ]
Chu, Hongwan [1 ]
Duan, Hongquan [1 ]
机构：
[1] Tianjin Med Univ, Res Ctr Basic Med Sci, Sch Pharmaceut Sci, Tianjin 300070, Peoples R China
[2] Tianjin Prov Corps Hosp, Tianjin 300162, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China
来源：
MOLECULES | 2010年 / 15卷 / 12期
基金：
国家教育部科学基金资助;
关键词：
trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity; INHIBITORS; IDENTIFICATION; FLAVONOIDS; GLYCOSIDES; MECHANISM; SCAFFOLD; LEAVES; RATS;
D O I：
10.3390/molecules15129174
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, H-1-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
引用
收藏
页码：9174 / 9183
页数：10
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