Cell-type specific innervation of cortical pyramidal cells at their apical dendrites

被引:46
|
作者
Karimi, Ali [1 ]
Odenthal, Jan [1 ]
Drawitsch, Florian [1 ]
Boergens, Kevin M. [1 ]
Helmstaedter, Moritz [1 ]
机构
[1] Max Planck Inst Brain Res, Dept Connect, Frankfurt, Germany
来源
ELIFE | 2020年 / 9卷
关键词
NEURONS IN-VITRO; PROJECTION NEURONS; ACTION-POTENTIALS; CALCIUM DYNAMICS; CEREBRAL-CORTEX; CA2+ SPIKES; INHIBITION; MORPHOLOGY; SYNAPSES; LAYER-5;
D O I
10.7554/eLife.46876
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We investigated the synaptic innervation of apical dendrites of cortical pyramidal cells in a region between layers (L) 1 and 2 using 3-D electron microscopy applied to four cortical regions in mouse. We found the relative inhibitory input at the apical dendrite's main bifurcation to be more than 2-fold larger for L2 than L3 and L5 thick-tufted pyramidal cells. Towards the distal tuft dendrites in upper L1, the relative inhibitory input was at least about 2-fold larger for L5 pyramidal cells than for all others. Only L3 pyramidal cells showed homogeneous inhibitory input fraction. The inhibitory-to-excitatory synaptic ratio is thus specific for the types of pyramidal cells. Inhibitory axons preferentially innervated either L2 or L3/5 apical dendrites, but not both. These findings describe connectomic principles for the control of pyramidal cells at their apical dendrites and support differential computational properties of L2, L3 and subtypes of L5 pyramidal cells in cortex.
引用
收藏
页数:23
相关论文
共 50 条
  • [1] Cell-type specific inhibitory plasticity in subicular pyramidal cells
    Guinet, Alix
    Grosser, Sabine
    Oezbay, Duru
    Behr, Joachim
    Vida, Imre
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2024, 18
  • [2] REGENERATIVE ACTIVITY IN APICAL DENDRITES OF PYRAMIDAL CELLS IN NEOCORTEX
    AMITAI, Y
    FRIEDMAN, A
    CONNORS, BW
    GUTNICK, MJ
    CEREBRAL CORTEX, 1993, 3 (01) : 26 - 38
  • [3] Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area
    Groh, Alexander
    Meyer, Hanno S.
    Schmidt, Eric F.
    Heintz, Nathaniel
    Sakmann, Bert
    Krieger, Patrik
    CEREBRAL CORTEX, 2010, 20 (04) : 826 - 836
  • [4] Branch specific and spike-order specific action potential invasion in basal, oblique, and apical dendrites of cortical pyramidal neurons
    Zhou, Wen-Liang
    Short, Shaina M.
    Rich, Matthew T.
    Oikonomou, Katerina D.
    Singh, Mandakini B.
    Sterjanaj, Enas V.
    Antic, Srdjan D.
    NEUROPHOTONICS, 2015, 2 (02)
  • [5] Cell-type specific alterations of cortical interneurons in schizophrenic patients
    Kalus, P
    Bondzio, J
    Federspiel, A
    Müller, TJ
    Zuschratter, W
    NEUROREPORT, 2002, 13 (05) : 713 - 717
  • [6] Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites
    Branco, Tiago
    Haeusser, Michael
    NEURON, 2011, 69 (05) : 885 - 892
  • [7] Differentiation of Apical and Basal Dendrites in Pyramidal Cells and Granule Cells in Dissociated Hippocampal Cultures
    Wu, You Kure
    Fujishima, Kazuto
    Kengaku, Mineko
    PLOS ONE, 2015, 10 (02):
  • [8] METRICAL INVESTIGATIONS ABOUT THE POSTNATAL-DEVELOPMENT OF THE APICAL DENDRITES OF THE CORTICAL PYRAMIDAL NEURONS IN RAT
    BOHM, O
    SCHIERHORN, H
    JOURNAL FUR HIRNFORSCHUNG, 1981, 22 (04): : 409 - 427
  • [9] Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
    Aghajanian, GK
    Marek, GJ
    NEUROPHARMACOLOGY, 1997, 36 (4-5) : 589 - 599
  • [10] Cell-type specific regulation of cortical excitability through the allatostatin receptor system
    Ikrar, Taruna
    Shi, Yulin
    Velasquez, Tomoko
    Goulding, Martyn
    Xu, Xiangmin
    FRONTIERS IN NEURAL CIRCUITS, 2012, 6