Polybrominated diphenyl ethers from the marine organisms Lendenfeldia dendyi and Sinularia dura with anti-MRSa activity

被引：15
|
作者：
Radwan, Mohamed M. [1 ]
Wanas, Amira S. [1 ]
Fronczek, Frank R. [2 ]
Jacob, Melissa R. [1 ]
Ross, Samir A. [1 ,3 ]
机构：
[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Louisiana State Univ, Coll Sci, Dept Chem, Baton Rouge, LA 70803 USA
[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Dept Biomol Sci, University, MS 38677 USA
来源：
MEDICINAL CHEMISTRY RESEARCH | 2015年 / 24卷 / 09期
关键词：
Polybrominated diphenyl ethers; Lendenfeldia; Sinularia; MRSa; SOFT CORAL; SPONGE; SESTERTERPENES; DITERPENOIDS; HERBACEA;
D O I：
10.1007/s00044-015-1386-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Bioassay-guided fractionation of the marine sponge Lendenfeldia dendyi and the soft coral Sinularia dura resulted in the isolation of five polybrominated diphenyl ethers (1-5). The structures of the isolated compounds were determined using spectroscopic methods (1D and 2D NMR) and HRMS analyses. The absolute structures of compounds 1 and 2 were confirmed by X-ray analysis. Antimicrobial testing of the isolated compounds along with the acetylated derivative of compound 2 (2a) indicated that they displayed a significant and selective activity against methicillin-resistant Staphylococcus aureus (MRSa) with IC50 values of < 0.04-1.18 mu M. The antimalarial and antileishmanial activities of the isolated compounds were also evaluated.
引用
收藏
页码：3398 / 3404
页数：7
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