Effects of total intravenous anesthesia and combined general-epidural anesthesia on erythrocyte immunity in patients undergoing laparoscopic resection of ovarian tumor

Objective: To analyze the effects of two different anesthesia methods, total intravenous anesthesia (IVA) and combined general-epidural anesthesia (EIVA), on erythrocyte immunity in patients undergoing laparoscopic resection of ovarian tumor. Methods: A total of 100 patients who were prepared for the laparoscopic resection of ovarian tumor in our hospital were recruited as subjects. The patients either received IVA or EIVE for the surgery in a random way. Samples of venous blood were collected across different time points which were before (T1) and 30 min after (T2) anesthesia, 1 h intra-operation (T3), 24 h (T4), 48 h (T5) and 72 h (T6) after operation, and the changes of erythrocyte immune functions were measured, including the rate of red blood cell C3b receptor rosette (RRCR), rate of red blood cell immune complex rosette (RRICR), rate of red blood cell circulating immune complex rosette (RRCICR), and rate of tumor red blood cell rosette (RTRR). Results: Similar variation patterns were observed in both groups regarding the values of RRCR, RRICR, RRCICR and RTRR before and after anesthesia; however, from T2 to T5, the levels of these indices in IVA group decreased more than those in EIVA group (P<0.05). Conclusion: Anesthesia could cause harm to the erythrocyte immunity in patients, however, compared with IVA, the damage by EIVA appeared to less.