Survival and risk factors associated with mortality in people living with HIV from 2005 to 2018 in Nanjing, China

被引:6
|
作者
Zhu, Zhengping [1 ]
Xu, Yuanyuan [1 ]
Wu, Sushu [1 ]
Li, Xin [1 ]
Shi, Hongjie [1 ]
Dong, Xiaoxiao [2 ]
Xu, Wenjiong [2 ]
机构
[1] Nanjing Municipal Ctr Dis Control & Prevent, Dept AIDS & STDs Control & Prevent, Nanjing, Peoples R China
[2] Nanjing Municipal Ctr Dis Control & Prevent, Dept Microbiol Test, Nanjing, Peoples R China
关键词
HIV; AIDS; survival; mortality; treatment;
D O I
10.3389/fpubh.2022.989127
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Although the introduction of antiretroviral therapy (ART) decreased the mortality of people living with Human Immunodeficiency Virus (PLHIV), substantially, hundreds of thousands of people are dying of AIDS each year. The accurate survival patterns and factors related to death among PLHIV were rarely reported. In this study, we evaluated survival status and identified factors associated with death among PLHIV in Nanjing. Methods: We conducted a retrospective analysis of PLHIV followed-up in Nanjing and registered to the national HIV/AIDS comprehensive management information system from 2005 to 2018. We used the life table to calculate the cumulative survival rates. We applied the Kaplan-Meier to calculate median survival times and employed cox hazard proportional regression to analyze the associated factors related to death. Results: The median survival time of PLHIV was 11.8 (95%CI:11.6-11.9) years from 2005 to 2018. Among 4,235 PLHIV included in this study, 7.5% had died of AIDS-related disease and the AIDS-related mortality rate was 2.0/100 PYs. The cumulative proportion surviving at the end of the interval was 95.2% over the 1st year, 94.0% over the 2nd year, 91.8% over the 5th year, and 85.4% over the 10th year, respectively. PLHIV who unaccepted ART showed a greater risk of death compared to those who accepted ART (AHR = 16.2, 95%CI:11.9 similar to 22.2). For baseline CD4 count, compared to CD4 < 200 cell/mu L, higher CD4 count was demonstrated as a protective factor, with AHR = 0.2 (95%CI: 0.1 similar to 0.3) for >= 500 cell/mu L AHR = 0.3 (95%CI:0.2 similar to 0.4) for 350 similar to 499 cell mu L, AHR = 0.4 (95%CI:0.3 similar to 0.6 for 200 similar to 349 cell/mu L). In addition, we observed a higher death risk in PLHIV who were screened through outpatient (AHR = 1.6, 95%CI: 1.1 similar to 2.2) and inpatient (AHR = 1.6, 95%CI: 1.1 similar to 2.5) compared to through VCT; the age of diagnosis was >= 50 years old (AHR = 9.5, 95%CI: 3.7 similar to 24.1) and 25 similar to 49 years old (AHR = 5.0, 95%CI: 2.0 similar to 12.3) compared to <= 24 years old; educated from junior and below (AHR = 3.4, 95%CI: 2.3 similar to 5.1) and Senior high school (AHR = 1.7, 95%CI: 1.1 similar to 2.7) compared to college and above. Conclusion: The AIDS-related mortality among PLHIV in Nanjing was relatively low. A higher risk for AIDS-related deaths were observed among PLHIV who unaccepted ART, whose baseline CD4 cell count was<200 cell/mu L, older age, and lower educated.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Factors associated with the quality of life of people living with HIV in Finland
    Nobre, Nuno
    Pereira, Marco
    Roine, Risto P.
    Sintonen, Harri
    Sutinen, Jussi
    QUALITY OF LIFE RESEARCH, 2016, 25 : 170 - 171
  • [42] Prevalence of HBV/HCV Co-Infection and Associated Risk Factors in People Living with HIV
    Senoglu, Sevtap
    Yesilbag, Zuhal
    Karaosmanoglu, Hayat Kumbasar
    Aydin, Ozlem Altuntas
    HEPATITIS MONTHLY, 2020, 20 (04)
  • [43] Risk factors for severe hypertriglyceridaemia in people living with HIV in Guatemala
    Ortiz, D. W.
    Marroquin, H. E.
    Larson, L.
    Franco, K. B.
    Spec, A.
    Melendez, J. R.
    Pinzon, R.
    Samayoa, A. J.
    Mejia-Chew, C.
    O'Halloran, J. A.
    ANTIVIRAL THERAPY, 2020, 25 : A40 - A41
  • [44] FACTORS ASSOCIATED WITH HIV INFECTION AMONG CAREGIVERS OF PEOPLE LIVING WITH HIV/AIDS
    Guo, Yan
    Zeng, Chengbo
    Zhang, Hanxi
    Cai, Wiping
    Sun, Yipeng
    Chen, Tingting
    Guo, Zihan
    Zhu, Yajing
    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 2016, 23 : S254 - S255
  • [45] Epidemiological trends of severely immunosuppressed people living with HIV at time of starting antiretroviral treatment in China during 2005-2018
    Hou, Yuying
    Liu, Jiaye
    Zhao, Yan
    Wu, Yasong
    Ma, Ye
    Zhao, Decai
    Dou, Zhihui
    Liu, Zhongfu
    Shi, Ming
    Jiao, Yanmei
    Huang, Huihuang
    Wu, Zunyou
    Wang, Lifeng
    Han, Mengjie
    Wang, Fu-Sheng
    JOURNAL OF INFECTION, 2022, 84 (03) : 400 - 409
  • [46] Excess mortality and associated factors among people living with HIV initiating highly active antiretroviral therapy in Luzhou, China 2006-2020
    Niu, Dandan
    Xiao, Ticheng
    Chen, Yuanyi
    Tang, Houlin
    Chen, Fangfang
    Cai, Chang
    Qin, Qianqian
    Zhao, Decai
    Jin, Yichen
    Wang, Shi
    Hou, Yushan
    Lu, Zhen
    Yang, Luoyao
    Liu, Hong
    Xie, Dongqin
    Zou, Huachun
    Lyu, Fan
    BMC INFECTIOUS DISEASES, 2023, 23 (01)
  • [47] ‘Trend in premature mortality from four major NCDs in Nanjing, China, 2007–2018’
    Huafeng Yang
    Yali Fu
    Xin Hong
    Hao Yu
    Weiwei Wang
    Fengxia Sun
    Jinyi Zhou
    Nan Zhou
    BMC Public Health, 21
  • [48] Prevalence of and factors associated with advanced HIV disease among newly diagnosed people living with HIV in Guangdong Province, China
    Jiang, Hongbo
    Liu, Jun
    Tan, Zhimin
    Fu, Xiaobing
    Xie, Yingqian
    Lin, Kaihao
    Yan, Yao
    Li, Yan
    Yang, Yi
    JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2020, 23 (11)
  • [49] Social support status and associated factors among people living with HIV/AIDS in Kunming city, China
    Yi Li
    Xiao-Wen Zhang
    Bin Liao
    Jun Liang
    Wen-Jie He
    Jun Liu
    Yao Yang
    Yun-Hai Zhang
    Tao Ma
    Jing-Ying Wang
    BMC Public Health, 21
  • [50] Serostatus disclosure and associated factors among people living with HIV/AIDS( PLWHA) in Liuzhou City,China
    LinFeng Hu
    YuJing Zhang
    MingQiang Li
    XianXiang Feng
    Juan Liu
    Jing Ni
    Han Cen
    Jie Liu
    DongQing Ye
    中华疾病控制杂志, 2014, (03) : 185 - 189