3,4-Annulated Indoles via Tandem Cyclopropane Ring-Opening/ Conia-ene and Michael Addition/Conia-ene Reactions

被引：13
|
作者：
Cochrane, Shane R. [1 ]
Kerr, Michael A. [1 ]
机构：
[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 30期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ALKALOIDS; FUNCTIONALIZATION; 3-ALKYLINDOLES;
D O I：
10.1021/acs.orglett.2c01810
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Alkynyl indoles, when treated with a benzylidene malonate or a donor-acceptor cyclopropane in the presence of a zinc halide, furnished 3,4-hexannylated or 3,4-heptannulated products, respectively, in fair to excellent yields. The reaction proceeds via a tandem addition/Conia-ene cyclization.
引用
收藏
页码：5509 / 5512
页数：4
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