Enhanced healing of mitomycin C-treated wounds in rats using inbred adipose tissue-derived stromal cells within an atelocollagen matrix

被引：54
|
作者：
Nambu, Masaki
Ishihara, Masayuki
Nakamura, Shingo
Mizuno, Hiroshi
Yanagibayashi, Satoshi
Kanatani, Yasuhiro
Hattori, Hidemi
Takase, Bonpei
Ishizuka, Takamitsu
Kishimoto, Satoko
Amano, Yoshiko
Yamamoto, Naoto
Azuma, Ryuichi
Kiyosawa, Tomoharu
机构：
[1] Natl Def Med Coll, Inst Res, Dept Plast & Reconstruct Surg, Tokorozawa, Saitama 3598513, Japan
[2] Natl Def Med Coll, Dept Surg 2, Tokorozawa, Saitama, Japan
[3] Nippon Med Sch, Dept Plast & Reconstruct Surg, Bunkyo Ku, Tokyo 113, Japan
来源：
WOUND REPAIR AND REGENERATION | 2007年 / 15卷 / 04期
关键词：
D O I：
10.1111/j.1524-475X.2007.00258.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim of this study was to evaluate the potential accelerating effects of an adipose tissue-derived stromal cells (ATSC)-containing atelocollagen matrix with silicone membrane (ACMS) for repairing mitomycin C-treated healing-impaired wounds. Mitomycin C was applied to full-thickness skin incisions in this study to create a healing-impaired wound model in rat. After thoroughly washing out the mitomycin C from the wound, ACMS alone or ATSC-containing ACMS was applied to the wounds. Histological sections of the wounds were then prepared at indicated time periods after the treatments. These results indicated significantly advanced granulation tissue and capillary formations in the healing-impaired wounds treated with ATSC-containing ALMS compared with those treated with ACMS alone. Thus, this study suggested that transplantation of inbred ATSC-containing ALMS is effective for repairing healing-impaired wounds.
引用
收藏
页码：505 / 510
页数：6
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