In the current social background of financial globalization, the United States subprime crisis outbreak in 2007 quickly evolved into the global financial tsunami, resulting in cranky global financial system, brings new challenges to the development of commercial banks in China. The study is the impact of the development of intermediary business on the profitability of commercial banks in China will provide a theoretical basis for the development of commercial banks in China. First of all, study the influence of intermediate business on the development of commercial banks has been proposed in the literature. Secondly, we processed the collected data by regression model, and analyzed the situation of the development of intermediary business on the commercial banks in China in recent years. Finally, we put forward some suggestions for the development of intermediate business of commercial banks according to the analysis results and the Chinese national conditions. The results show that the intermediate business income has no significant impact on the profitability of banks, and even negative correlation. It is hoped that this research can provide reference for the relevant academic research in the future and be beneficial to the development of commercial banks in China.