Simultaneous quantification of 12 bioactive components of Ligusticum chuanxiong Hort. by high-performance liquid chromatography

被引：83
|
作者：
Yan, R
Li, SL
Chung, HS
Tam, YK
Lin, G [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Pharmacol, Fac Med, Shatin, Hong Kong, Peoples R China
[2] Kinetana Hong Kong Herbal Pharmaceut Ltd, Shatin, Hong Kong, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 37卷 / 01期
关键词：
Ligusticum chuanxiong Hort; Rhizoma Chuanxiong; HPLC quantification; quality control;
D O I：
10.1016/j.jpba.2004.09.054
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive and specific HPLC-UV method has been developed, for the first time, to simultaneously quantify 12 bioactive ingredients in Ligusticuin chuanxiong Hort. (Rhizoma Chuanxiong). This assay was fully validated in respect to precision, accuracy and sensitivity. This method was successfully applied to quantify twelve ingredients in six different Chuanxiong samples. The results demonstrated significant variations in the total content and quantity of each of the main bioactive compounds in different herbs, indicating that quality control of bioactive ingredients in Chuanxiong is critical to ensure its clinical benefits. This assay can be readily utilized as quality control method for Chuanxiong. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：87 / 95
页数：9
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