Prokaryotic toxin-antitoxin stress response loci

被引：874

作者：

Gerdes, K ^{[1
]}

Christensen, SK

Lobner-Olesen, A

机构：

[1] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark

[2] Roskilde Univ, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 05期

关键词：

D O I：

10.1038/nrmicro1147

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although toxin-antitoxin gene cassettes were first found in plasmids, recent database mining has shown that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria. For example, Mycobacterium tuberculosis has 38 chromosomal toxin-antitoxin loci, including 3 relBE and 9 mazEF loci. ReIE and MazF are toxins that cleave mRNA in response to nutritional stress. ReIE cleaves mRNAs that are positioned at the ribosomal A-site, between the second and third nucleotides of the A-site codon. It has been proposed that toxin-antitoxin loci function in bacterial programmed cell death, but evidence now indicates that these loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress.

引用

页码：371 / 382

页数：12

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