Quantitative trait loci implicated in corpus callosum midsagittal area in mice

被引：6
|
作者：
Le Roy, I [1 ]
Perez-Diaz, F [1 ]
Roubertoux, P [1 ]
机构：
[1] UPR CNRS 9074, Inst Transgenose, F-45071 Orleans 02, France
来源：
BRAIN RESEARCH | 1998年 / 811卷 / 1-2期
关键词：
corpus callosum; mouse; gene mapping; CCrSQTL(1); CCrSQTL(2);
D O I：
10.1016/S0006-8993(98)00975-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BINJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F(2)s. Two loci linked to this measure were found: the CCrSQTL(1) and CCrSeTL2 at 87 and 67 centiMorgans from the centromere on chromosomes 1 and 4 respectively. The two loci interacted significantly. The total source of genetic variation contributed to 25% of the observed variance; (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：173 / 176
页数：4
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