Lack of Association of Polymorphisms in IL22 and IL22RA1 Genes with Fibrosis Severity in Patients with Chronic Hepatitis C

被引：0
|
作者：
de Brito, Rodrigo Jose Videres Cordeiro [1 ,2 ]
do Carmo, Rodrigo Feliciano [3 ,8 ]
Silva, Bruna Manuella Souza [3 ]
Barbosa Jr, Walter Lins [4 ]
Vasconcelos, Luydson Richardson Silva [4 ]
Pereira, Leila Maria Moreira Beltrao [1 ,5 ,6 ]
Moura, Patricia [1 ,7 ]
机构：
[1] Univ Pernambuco UPE, Postgrad Program Hlth Sci, Recife, Brazil
[2] Fed Univ Sao Francisco Valley UNIVASF, Coll Med, Petrolina, Brazil
[3] Fed Univ Sao Francisco Valley UNIVASF, Coll Pharm, Petrolina, Brazil
[4] Aggeu Magalhaes Inst IAM FIOCRUZ, Dept Parasitol, Recife, Brazil
[5] Univ Pernambuco UPE, Fac Med, Recife, Brazil
[6] Liver Inst Pernambuco IFP, Recife, Brazil
[7] Univ Pernambuco UPE, Inst Biol Sci, Recife, Brazil
[8] Univ Fed Vale Sao Francisco, Coll Pharm, Ave Jose de Sa Manicoba,s-n,Ctr, BR-56304917 Petrolina, Brazil
来源：
VIRAL IMMUNOLOGY | 2022年 / 35卷 / 07期
关键词：
fibrosis; HCV; IL-22; interleukin; polymorphism; INTERLEUKIN-22; IL-22; IMMUNITY; VIRUS;
D O I：
10.1089/vim.2022.0034
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The IL-22 pathway has been shown to play an important role in the pathogenesis of liver fibrosis. However, little is known about the role of single-nucleotide polymorphisms (SNPs) in IL-22-related genes in relation to the severity of liver fibrosis. This study aimed to investigate the association of polymorphisms in IL22 and IL22RA1 genes with the severity of liver fibrosis in patients with chronic hepatitis C. A total of 326 patients (165 with mild fibrosis and 161 with severe fibrosis) were included. Four SNPs in IL22 (rs1179251, rs2227473, rs1012356, and rs2227485) and two in IL22RA1 (rs4648936 and rs3795299) were evaluated by real-time PCR. No significant association was observed between the polymorphisms studied and the severity of liver fibrosis. The SNPs rs1179251, rs2227473, rs1012356, and rs2227485 in IL22 and rs4648936 and rs3795299 in IL22RA1 may not be involved in the pathogenesis of liver fibrosis in patients with chronic hepatitis C.
引用
收藏
页码：509 / 513
页数：5
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