The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas

被引：173

作者：

Ecker, Joseph R. ^{[1
,2
]}

Geschwind, Daniel H. ^{[3
,4
]}

Kriegstein, Arnold R. ^{[5
]}

Ngai, John ^{[6
]}

Osten, Pavel ^{[7
]}

Polioudakis, Damon ^{[3
,4
]}

Regev, Aviv ^{[8
,9
]}

Sestan, Nenad ^{[10
,11
,12
,13
]}

Wickersham, Ian R. ^{[14
]}

Zeng, Hongkui ^{[15
]}

机构：

[1] Salk Inst Biol Studies, Genom Anal Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Program Neurogenet, Dept Neurol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Program Neurogenet, Dept Human Genet, Los Angeles, CA 90095 USA

[5] Univ Calif San Francisco, Dept Neurol, Eli & Edythe Broad, Ctr Regenerat Med & Stem Cell Res, San Francisco, CA 94143 USA

[6] Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Funct Genom Lab QB3, Berkeley, CA 94720 USA

[7] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

[8] MIT, Klarman Cell Observ, Broad Inst MIT & Harvard, Dept Biol,Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA

[9] MIT, Howard Hughes Med Inst, Cambridge, MA 02142 USA

[10] Yale Sch Med, Kavli Inst Neurosci, Program Cellular Neurosci Neurodegenerat & Repair, Yale Child Study Ctr,Dept Neurosci, New Haven, CT 06510 USA

[11] Yale Sch Med, Kavli Inst Neurosci, Program Cellular Neurosci Neurodegenerat & Repair, Yale Child Study Ctr,Dept Genet, New Haven, CT 06510 USA

[12] Yale Sch Med, Kavli Inst Neurosci, Program Cellular Neurosci Neurodegenerat & Repair, Yale Child Study Ctr,Dept Psychiat, New Haven, CT 06510 USA

[13] Yale Sch Med, Kavli Inst Neurosci, Program Cellular Neurosci Neurodegenerat & Repair, Yale Child Study Ctr,Dept Comparat Med, New Haven, CT 06510 USA

[14] MIT, McGovern Inst Brain Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[15] Allen Inst Brain Sci, Seattle, WA 98109 USA

来源：

NEURON | 2017年 / 96卷 / 03期

关键词：

GENE-EXPRESSION ATLAS; MESSENGER-RNA-SEQ; SINGLE-CELL; NERVOUS-SYSTEM; CHROMATIN ACCESSIBILITY; NEURONAL DIVERSITY; TRANSCRIPTIONAL REGULATION; TEMPORAL DYNAMICS; GABAERGIC NEURONS; NEURAL CIRCUITS;

D O I：

10.1016/j.neuron.2017.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans.

引用

页码：542 / 557

页数：16

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