Selective Simultaneous Determination of Paracetamol and Uric Acid Using a Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotube/Chitosan Composite

被引：36

作者：

Babaei, Ali ^{[1
,2
]}

Garrett, David J. ^{[2
]}

Downard, Alison J. ^{[2
]}

机构：

[1] Univ Arak, Dept Chem, Arak 38156, Iran

[2] Univ Canterbury, Dept Chem, Christchurch 8140, New Zealand

来源：

ELECTROANALYSIS | 2011年 / 23卷 / 02期

关键词：

Paracetamol; Uric acid; Carbon nanotubes; Chitosan; Modified glassy carbon; NANOTUBES-CHITOSAN COMPOSITE; FLOW-INJECTION; DIRECT ELECTROCHEMISTRY; VOLTAMMETRIC METHOD; ACETAMINOPHEN; OXIDATION; ENZYMES; TABLETS; SYSTEM; SERUM;

D O I：

10.1002/elan.201000406

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A multiwalled carbon nanotube/chitosan modified glassy carbon electrode (MWCNTs-CHT/GCE) has been used for simultaneous determination of paracetamol (PAR) and uric acid (UA). The measurements were carried out using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA). DPV measurements showed a linear relationship between oxidation peak current and concentration of PAR and UA in phosphate buffer (pH 7) over the concentration range 2 mu M to 250 mu M, and 10 mu M to 400 mu M, respectively. The analytical performance of this sensor has been evaluated for detection of PAR and UA in human serum and human urine with satisfactory results.

引用

页码：417 / 423

页数：7

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