Acute in vitro effects of dronedarone, an iodine-free derivative, and amiodarone, on the rabbit sinoatrial node automaticity: A comparative study

被引：15

作者：

Celestino, Daniela ^{[1
]}

Medei, Emiliano ^{[1
]}

Moro, Sandra ^{[1
]}

Elizari, Marcelo V. ^{[1
]}

Sicouri, Serge ^{[1
]}

机构：

[1] Hosp Ramos Mejia, Lab Electrofisiol Celular, Div Cardiol, Buenos Aires, DF, Argentina

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2007年 / 12卷 / 03期

关键词：

antiarrhythmic drugs; in vitro study; sinus node; automaticity;

D O I：

10.1177/1074248407303225

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amiodarone is a potent antiarrhythmic drug commonly used in the treatment of supraventricular and ventricular arrhythmias. Dronedarone is a recently developed iodine-free compound (Sanofi Recherche), structurally related to amiodarone. Amiodarone and dronedarone have shown similar long-term effects on sinoatrial node automaticity in vivo and in vitro in the rabbit heart. In the present study, we used a microelectrode technique to compare the acute in vitro electrophysiologic effects of amiodarone (100 mu M) and dronedarone (100 mu M) on the rabbit sinus node. Like amiodarone, dronedarone induces a marked reduction in sinus node automaticity, evidenced by decreases in spontaneous beating rate, action potential amplitude, and slope of phase 4 depolarization. Isoproterenol dose-dependently increases sinus node automaticity in the presence of either amiodarone or dronedarone. The data suggest that dronedarone may be a useful antiarrhythmic alternative to amiodarone in the treatment of supraventricular arrhythmias.

引用

页码：248 / 257

页数：10