Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo

被引：33

作者：

Mumba, Dieudonne ^{[1
]}

Bohorquez, Elaine ^{[2
]}

Messina, Jane ^{[3
]}

Kande, Victor ^{[4
]}

Taylor, Steven M. ^{[2
]}

Tshefu, Antoinette K. ^{[5
]}

Muwonga, Jeremie ^{[6
]}

Kashamuka, Melchior M. ^{[2
]}

Emch, Michael ^{[3
]}

Tidwell, Richard ^{[7
]}

Buscher, Philippe ^{[8
]}

Meshnick, Steven R. ^{[2
]}

机构：

[1] Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[2] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Geog, Chapel Hill, NC USA

[4] Programme Natl Lutte Trypanosomiase Humaine Afric, Kinshasa, DEM REP CONGO

[5] Univ Kinshasa, Kinshasa Sch Publ Hlth, Kinshasa, DEM REP CONGO

[6] Programme Natl Lutte SIDA, Kinshasa, DEM REP CONGO

[7] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA

[8] Inst Trop Med, Dept Parasitol, B-2000 Antwerp, Belgium

来源：

PLOS NEGLECTED TROPICAL DISEASES | 2011年 / 5卷 / 08期

关键词：

SEROLOGICAL TESTS; BRUCEI; BLOOD; SAMPLES;

D O I：

10.1371/journal.pntd.0001246

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Human African Trypanosomiasis (HAT) is a major public health problem in the Democratic Republic of the Congo (DRC). Active and passive surveillance for HAT is conducted but may underestimate the true prevalence of the disease. We used ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007 Demographic and Health Survey. 26 samples were positive by ELISA. Three of these were also positive by trypanolysis and/or PCR. From these data, we estimate that there were 18,592 people with HAT (95% confidence interval, 4,883-32,302) in the DRC in 2007, slightly more than twice as many as were reported.

引用

页数：5

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