Mesoscale microscopy and image analysis tools for understanding the brain

被引：24
|
作者：
Tyson, Adam L. [1 ]
Margrie, Troy W. [1 ]
机构：
[1] UCL, Sainsbury Wellcome Ctr, 25 Howland St, London W1T 4JG, England
来源：
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2022年 / 168卷
基金：
英国惠康基金;
关键词：
Neuroscience; whole Brain microscopy; Image registration; Segmentation; Visualisation; GENE-EXPRESSION; 3-DIMENSIONAL VISUALIZATION; AXONAL PROJECTIONS; RESOLUTION; FRAMEWORK; ATLAS; RECONSTRUCTION; CONNECTIVITY; TOMOGRAPHY; ANNOTATION;
D O I：
10.1016/j.pbiomolbio.2021.06.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last ten years, developments in whole-brain microscopy now allow for high-resolution imaging of intact brains of small animals such as mice. These complex images contain a wealth of information, but many neuroscience laboratories do not have all of the computational knowledge and tools needed to process these data. We review recent open source tools for registration of images to atlases, and the segmentation, visualisation and analysis of brain regions and labelled structures such as neurons. Since the field lacks fully integrated analysis pipelines for all types of whole-brain microscopy analysis, we propose a pathway for tool developers to work together to meet this challenge.
引用
收藏
页码：81 / 93
页数：13
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