No preferential loss of paternal 19q alleles in oligodendroglial tumors

被引：8

作者：

Hartmann, C

Mueller, W

Lass, U

Stockhammer, F

von Eckardstein, K

Veelken, J

Jeuken, J

Wick, W

von Deimling, A

机构：

[1] Humboldt Univ, Charite, Inst Neuropathol, Dept Neuropathol, D-13353 Berlin, Germany

[2] Humboldt Univ, Charite, Dept Neurosurg, D-13353 Berlin, Germany

[3] Helios Kliniken GmbH, Dept Neurosurg, Berlin, Germany

[4] Vivantes Klinikum Neukolln, Dept Neurosurg, Berlin, Germany

[5] Univ Nijmegen Hosp, Dept Neurol, NL-6500 HB Nijmegen, Netherlands

[6] Univ Tubingen, Dept Neurol, D-7400 Tubingen, Germany

来源：

ANNALS OF NEUROLOGY | 2003年 / 54卷 / 02期

关键词：

D O I：

10.1002/ana.10649

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recently, exclusive loss of paternal 19q alleles in six of six oligodendrogliomas has been reported, indicating that parental imprinting plays a role in these tumors. We examined a series of 10 oligodendrogliomas and 3 oligoastrocytomas with allelic losses on 1p and 19q for the parental origin of the lost alleles. Ten cases lost paternal 1p alleles and 3 cases lost maternal alleles. For 19q, six cases had loss of paternal alleles and seven cases of had loss of maternal alleles. These random distributions do not support the hypothesis that parental imprinting accounts for inactivation of the putative oligodendroglioma tumor suppressor genes.

引用

页码：256 / 258

页数：3

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