Anti-oxidant capacity and anti-tumor T cell function: A direct correlation

被引：9

作者：

Kesarwani, Pravin ^{[1
]}

Thyagarajan, Krishnamurthy ^{[1
]}

Chatterjee, Shilpak ^{[1
]}

Palanisamy, Viswanathan ^{[2
]}

Mehrotra, Shikhar ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Surg, Charleston, SC 29425 USA

[2] Med Univ S Carolina, Charleston, SC 29425 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 01期

关键词：

adoptive immunotherapy; melanoma; Thiols; T cell; OXIDATIVE STRESS; MEMORY;

D O I：

10.4161/2162402X.2014.985942

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Improving persistence and sustained function of effector CD8(+) T cell response is key for achieving significant tumor control in adoptive T cell immunotherapy protocols. Our recent report shows that high anti-oxidant property is central to potent anti-tumor effector T cells, and directly correlates to CD62L(hi) central memory, low glycolytic and low mitochondrial membrane potential phenotype, all of which may be linked and contribute to better tumor control.

引用

页数：3

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