H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis

被引：7

作者：

Ling, Xianlong ^{[1
]}

Zhang, Haoxiang ^{[1
]}

Shen, Caifei ^{[1
]}

Yan, Wu ^{[1
]}

Wang, Pu ^{[1
]}

Feng, Ji ^{[1
]}

Peng, Zhihong ^{[1
]}

Peng, Guiyong ^{[1
]}

Chen, Wensheng ^{[1
]}

Fang, Dianchun ^{[1
]}

机构：

[1] Third Mil Med Univ, Southwest Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China

来源：

INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷

基金：

中国国家自然科学基金;

关键词：

H; pylori; Mitochondrial microsatellite instability; IL-8; Gastric cancer; OXYGEN METABOLITE PRODUCTION; DUODENAL-ULCER DISEASE; HELICOBACTER-PYLORI; DNA-DAMAGE; OXIDATIVE STRESS; HUMAN CANCERS; NUCLEAR-DNA; IN-VIVO; INTERLEUKIN-8; CELLS;

D O I：

10.1186/s13027-016-0078-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bachground: To assess the correlation of H. pylori infection with mitochondrial microsatellite instability (mtMSI) and IL-8 in gastric carcinogenesis. Methods: H. pylori infection was evaluated through histology and a urease breath test; mtMSI was measured using PCR-single strand conformation polymorphism (PCR-SSCP); IL-8 was analyzed with ELISA methods. Results: The detection rate of mtMSI was significantly higher in specimens with H. pylori infection than in those without H. pylori infection (P < 0.05). The levels of IL-8 were significantly higher in specimens with mtMSI than in those without mtMSI (P < 0.01). An association of mtMSI with the intestinal histological type was found (P < 0.05). Increased IL-8 levels induced by H. pylori were related to the invasion, lymphnode spreading and clinical stage of gastric cancer (P < 0.05). Conclusions: H. pylori infection is related to mitochondrial microsatellite instability in the early steps of gastric cancer development. IL-8 may play a role in the development of mtMSI induced by H. pylori. Our results support a role for mtMSI in different mechanisms of gastric carcinogenesis.

引用

页数：8

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