Design and optimization of heterocyclic 4-azaxanthenes as potent and selective inhibitors of BACE1 for the treatment of Alzheimer's disease

被引：0

作者：

Marx, Isaac E. ^{[1
]}

Chen, Kui ^{[2
]}

Cheng, Alan C. ^{[2
]}

Dineen, Thomas A. ^{[1
]}

Epstein, Oleg ^{[1
]}

Esmay, Joel ^{[4
]}

Hickman, Dean ^{[4
]}

Kreiman, Chuck E. ^{[1
]}

Wahl, Robert C. ^{[3
]}

Wen, Paul H. ^{[5
]}

Weiss, Matthew M. ^{[1
]}

Whittington, Douglas A. ^{[2
]}

Wood, Stephen ^{[5
]}

Fremeau, Robert T. ^{[5
]}

White, Ryan D. ^{[1
]}

Patel, Vinod F. ^{[1
]}

机构：

[1] Amgen Inc, Dept Med Chem, Cambridge, MA 02142 USA

[2] Amgen Inc, Dept Mol Struct, Cambridge, MA 02142 USA

[3] Amgen Inc, Dept Mol Struct, Thousand Oaks, CA 91320 USA

[4] Amgen Inc, Dept Pharmacokinet & Drug Metab, Thousand Oaks, CA 91320 USA

[5] Amgen Inc, Dept Neurosci, Thousand Oaks, CA 91320 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 248卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

447-MEDI

引用

页数：1

共 50 条

[1] The potential for BACE1 inhibitors in the treatment of Alzheimer's disease
Hussain, I
IDRUGS, 2004, 7 (07) : 653 - 658
[2] BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
Ghosh, Arun K.
Osswald, Heather L.
CHEMICAL SOCIETY REVIEWS, 2014, 43 (19) : 6765 - 6813
[3] Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment
Coimbra, Judite R. M.
Marques, Daniela F. F.
Baptista, Salete J.
Pereira, Claudia M. F.
Moreira, Paula I.
Dinis, Teresa C. P.
Santos, Armanda E.
Salvador, Jorge A. R.
FRONTIERS IN CHEMISTRY, 2018, 6
[4] Computational modelling of potent β-secretase (BACE1) inhibitors towards Alzheimer's disease treatment
Ugbaja, Samuel C.
Sanusi, Zainab K.
Appiah-Kubi, Patrick
Lawal, Monsurat M.
Kumalo, Hezekiel M.
BIOPHYSICAL CHEMISTRY, 2021, 270
[5] A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment
Brati Das
Riqiang Yan
CNS Drugs, 2019, 33 : 251 - 263
[6] Discovery of novel BACE1 inhibitors for the treatment of Alzheimer's disease
Stamford, Andrew W.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
[7] A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment
Das, Brati
Yan, Riqiang
CNS DRUGS, 2019, 33 (03) : 251 - 263
[8] Development of BACE1 inhibitors for Alzheimer's disease
Guo, Tao
Hobbs, Doug W.
CURRENT MEDICINAL CHEMISTRY, 2006, 13 (15) : 1811 - 1829
[9] Advancements in BACE1 and non-peptide BACE1 inhibitors for Alzheimer's disease
Shah, Nishita P.
Solanki, Vivek S.
Gurjar, Archana S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (06): : 830 - 842
[10] Design and optimization of 2-aminooxazoline4-azaxanthene inhibitors of BACE1 for the treatment of Alzheimer's disease: Discovery of AMG-8718
Dineen, Thomas A.
Chen, Kui
Cheng, Alan C.
Derakhchan, Kathy
Epstein, Oleg
Esmay, Joel
Hickman, Dean
Kreiman, Chuck E.
Marx, Isaac E.
Wahl, Robert C.
Wen, Paul H.
Weiss, Matthew M.
Whittington, Douglas A.
Wood, Stephen
Fremeau, Robert T.
White, Ryan D.
Patel, Vinod F.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248

← 1 2 3 4 5 →