Fast-tracking steroid receptor crystallization

被引：0
|
作者：
Mader, Sylvie [1 ,2 ]
机构：
[1] Univ Montreal, Inst Res Immunol, Montreal, PQ H3C 3J7, Canada
[2] Univ Montreal, Canc & Biochem Dept, Montreal, PQ H3C 3J7, Canada
来源：
NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 04期
关键词：
D O I：
10.1038/nchembio0408-226
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Crystallographic analysis has been instrumental in revealing the molecular basis for the pharmacological properties of several natural and synthetic ligands of steroid receptors, but it is often a long and arduous process. A new method for stabilizing these receptors greatly accelerates this process, allowing generation of apo receptor crystals and the comparison of multiple structures to define pathway-specific interactions.
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页码：226 / 227
页数：3
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