New 1,8-naphthyridine-based probes for the selective fluorescence signalling of toxic cadmium: synthesis, photophysical studies and molecular modelling

被引：4
|
作者：
Mashraqui, Sabir H. [1 ]
Betkar, Rupesh [1 ]
Chandiramani, Mukesh [1 ]
Poonia, Kiran [1 ]
Quinonero, David [2 ]
Frontera, Antonio [2 ]
机构：
[1] Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India
[2] Univ Illes Balears, Dept Quim, Palma De Mallorca 07122, Baleares, Spain
来源：
SUPRAMOLECULAR CHEMISTRY | 2010年 / 22卷 / 09期
关键词：
1; 8-naphthyridine; fluorophore photophysical studies; fluorescent cadmium sensors; NMR analysis; molecular modelling; SENSOR; CHEMOSENSOR; ZINC; DESIGN; RECOGNITION; CARCINOGENESIS; NAPHTHYRIDINE; ENHANCEMENT; MISMATCHES; PRINCIPLES;
D O I：
10.1080/10610278.2010.491153
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Newly synthesised 1,8-naphthyridine-based molecular probes, NAP-1 and NAP-2, exhibit highly selective fluorescence responses towards the toxic cadmium over coordinatively competing Zn2+ and several other metal ions examined. On the one hand, NAP-1 (MeOH:H2O, v/v 80:20, pH 7.4) exhibits ca. 1.5 order of magnitude higher stability constant for Cd2+ over Zn2+; on the other hand, NAP-2 in MeOH offers unique selectivity only towards Cd2+, exhibiting both absorbance and emission red shifts as well as fluorescence enhancement. By 1H NMR analysis, the tetra-coordinated binding is indicated at least for the NAP-1+Cd2+ complex and theoretical calculations reveal relatively stronger binding of Cd2+ over Zn2+. [image omitted].
引用
收藏
页码：524 / 531
页数：8
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