Solvent-free Williamson synthesis: An efficient, simple, and convenient method for chemoselective etherification of phenols and bisphenols

被引：32
|
作者：
Massah, Ahmad R.
Mosharafian, Masumeh
Momeni, Ahamad R.
Aliyan, Hamid
Naghash, H. Javaherian
机构：
[1] Islamic Azad Univ, Shahreza Branch, Dept Chem, Shahreza, Isfahan, Iran
[2] Islamic Azad Univ, Falavarjan Branch, Dept Chem, Falavarjan, Isfahan, Iran
来源：
SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 11期
关键词：
chemoselective; bisphenols; etherification; phenols; solvent-free;
D O I：
10.1080/00397910701316268
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Etherification of phenols with dimethyl- and diethylsulfates and benzyl chloride was performed efficiently in the presence of a suitable solid base, NaHCO(3) or K(2)CO(3), under solvent-free conditions. The reaction proceeded rapidly at low temperature, and the corresponding ethers were obtained with high purity and excellent yield. Selective etherification of electron-poor phenols in the presence of electron-rich ones and also selective mono-etherification of bisphenols are the noteworthy advantages of this method. This method is environmentally friendly.
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页码：1807 / 1815
页数：9
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