Non-immune hydrops fetalis: A short review of etiology and pathophysiology

被引：113

作者：

Bellini, Carlo ^{[1
]}

Hennekam, Raoul C. M. ^{[2
,3
]}

机构：

[1] Univ Genoa, Dept Paediat, Neonatal Intens Care Unit, Gaslini Inst,IRCCS G Gaslini, I-16147 Genoa, Italy

[2] Univ Amsterdam, Acad Med Ctr, Dept Paediat, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Translat Genet, NL-1105 AZ Amsterdam, Netherlands

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART A | 2012年 / 158A卷 / 03期

关键词：

non-immune hydrops fetalis; fetal hydrops; pathogenesis; edema of the fetus; NIHF; pathophysiologic pathways; AMNIOTIC-FLUID VOLUME; OUTFLOW PRESSURE; UMBILICAL-CORD; WATER; PHYSIOLOGY; PLACENTA; ASPHYXIA; BRAIN; FETUS; AQUAPORINS;

D O I：

10.1002/ajmg.a.34438

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hydrops fetalis is an excessive accumulation of fetal fluid. Hydrops is traditionally classified into either immune or non-immune hydrops (NIHF), but in practice, nowadays in the Western world >90% of hydrops is of non-immune origin. The basis of the disorder is an imbalance in the regulation of fetal fluid movement between the vascular and interstitial space. We previously suggested a diagnostic flow-chart for NIHF. In this short review we describe the main mechanisms leading to NIHF. (c) 2012 Wiley Periodicals, Inc.

引用

页码：597 / 605

页数：9

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