The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish

被引：16
|
作者：
Powers, Jamie W. [2 ]
Mazilu, Jaime K. [1 ]
Lin, Shuo [3 ]
McCabe, Edward R. B. [1 ,4 ]
机构：
[1] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Mattel Childrens Hosp, Div Neonatol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
来源：
MOLECULAR GENETICS AND METABOLISM | 2010年 / 101卷 / 04期
关键词：
Diabetes mellitus; Hyperglycemia; Cortisol; Zebrafish; DIABETES-MELLITUS; GLUCOSE-INTOLERANCE; CORTISOL METABOLISM; AXIS; MEN;
D O I：
10.1016/j.ymgme.2010.09.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Since the 19505, scientists have attempted to characterize the relationship between diabetes mellitus (DM) and the hypothalamic-pituitary-adrenal (HPA) axis. Similar complications are seen in patients with diabetes and Cushing's syndrome, leading some to suggest that an underlying abnormality in the HPA axis may be responsible among those with DM. By inducing hyperglycemia in a zebrafish animal model, we show a direct correlation between glucose and cortisol levels. (C) 2010 Elsevier Inc. All rights reserved.
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页码：421 / 422
页数：2
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