Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C-H Activation Processes

被引：78
|
作者：
Bu, Qingqing [1 ]
Rogge, Torben [1 ]
Kotek, Vladislav [1 ]
Ackermann, Lutz [1 ]
机构：
[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 03期
关键词：
arylacetamides; density functional theory; homogeneous catalysis; mechanisms; ruthenium; LATE-STAGE DIVERSIFICATION; CATALYZED DIRECT ARYLATION; CROSS-COUPLING REACTIONS; BOND ACTIVATION; DIRECTING GROUP; BASIS-SETS; FUNCTIONALIZATION; HYDROARYLATION; ALKENYLATIONS; ARENES;
D O I：
10.1002/anie.201711108
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
C-H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C-H functionalization offers ample scopeincluding twofold oxidative C-H functionalizations and alkyne hydroarylationsthrough facile base-assisted internal electrophilic-type substitution (BIES) C-H ruthenation by weak O-coordination.
引用
收藏
页码：765 / 768
页数：4
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