Derivatization of Amino Acids and Peptides via Photoredox-Mediated Conjugate Addition

被引：40

作者：

Zhang, Olivia ^{[1
]}

Schubert, Jeffrey W. ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Discovery Chem, West Point, PA 19486 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 09期

关键词：

DERIVATIVES; ROUTE;

D O I：

10.1021/acs.joc.0c00635

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unnatural amino acids are key building blocks in therapeutically relevant peptides. Thus, the development of novel methods to increase the structural diversity of the unnatural amino acid pool is needed. Herein, a photoredox-mediated decarboxylative radical conjugate addition to dehydroalanine derivatives is disclosed. Mild, robust, and general conditions were identified and applied to the diastereoselective synthesis of unnatural amino acids and the late-stage derivatization of a tripeptide.

引用

页码：6225 / 6232

页数：8

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