The Y chromosome in the era of intracytoplasmic sperm injection: a personal review

被引:19
|
作者
Silber, Sherman J. [1 ,2 ]
机构
[1] St Lukes Hosp, Infertil Ctr St Louis, St Louis, MO 63017 USA
[2] Univ Amsterdam, Ctr Reprod Med, Amsterdam, Netherlands
关键词
Y chromosome; intracytoplasmic sperm injection; azoospermia; MESA; TESE; CANDIDATE SPERMATOGENESIS GENE; FACTOR-C REGION; MALE-INFERTILITY; DAZ GENE; AZOOSPERMIC MEN; SEX-CHROMOSOMES; PREGNANCY RATE; FOLLOW-UP; INTRACHROMOSOMAL RECOMBINATION; SEMINIFEROUS EPITHELIUM;
D O I
10.1016/j.fertnstert.2011.05.070
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The Y chromosome contains 60 multicopy genes composed of nine different gene families concentrated in regions of multiple repeat sequences called amplicons arranged in mirror images called palindromes. This pattern is susceptible to deletions caused by homologous recombination with itself, and can explain the presence of small numbers of sperm in otherwise azoospermic men. (Fertil Steril (R) 2011; 95: 2439-48. (C) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码:2439 / U459
页数:15
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