Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41

被引：3
|
作者：
Soonthornsata, Bongkot [1 ]
Tian, Yu-Shi [2 ]
Utachee, Piraporn [1 ]
Sapsutthipas, Sompong [1 ]
Isarangkura-na-ayuthaya, Panasda [3 ]
Auwanit, Wattana [3 ]
Takagi, Tatsuya [1 ,2 ]
Ikuta, Kazuyoshi [1 ,4 ]
Sawanpanyalert, Pathom [3 ]
Kawashita, Norihito [1 ,2 ]
Kameoka, Masanori [1 ,4 ]
机构：
[1] Thailand Japan Res Collaborat Ctr Emerging & Reem, Nonthaburi, Thailand
[2] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan
[3] Minist Publ Hlth, Dept Med Sci, Natl Inst Hlth, Nonthaburi 11000, Thailand
[4] Osaka Univ, Dept Virol, Microbial Dis Res Inst, Osaka, Japan
来源：
VIROLOGY | 2010年 / 405卷 / 01期
关键词：
HIV-1; Envelope glycoprotein gp41; alpha-helical heptad repeat; C34 fusion inhibitor; CRF01_AE; Subtypes; HIV-1 FUSION INHIBITOR; RESISTANT HIV-1; ENV CLONES; ENFUVIRTIDE; INFECTIONS; CORE; T-20; EMERGENCE; ENTRY;
D O I：
10.1016/j.virol.2010.06.012
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two alpha-helical heptad repeats. N-HR and C-HR, located in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp41, play an important role in membrane fusion by forming a 6-helix bundle. C34, a peptide mimicking C-HR, inhibits the formation of the 6-helix bundle, thus, it has potential as a novel antiretroviral compound In order to improve the inhibitory effect of C34 on HIV-1 replication, we designed new C34-derived peptides based on computational analysis of the stable conformation of the 6-helix bundle Newly designed peptides showed a stronger inhibitory effect on the replication of recombinant viruses containing CRF01_AE, subtype B or subtype C Env than C34 or a fusion inhibitor, T-20 In addition, these peptides inhibited the replication of a T-20-resistant virus We propose that these peptides could be applied to develop novel antiretroviral compounds to inhibit the replication of various subtypes of HIV-I as well as of T-20-resistant variants (C) 2010 Elsevier Inc All rights reserved
引用
收藏
页码：157 / 164
页数：8
相关论文
共 50 条
  • [1] Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region
    Isarangkura, NAP
    Li, GM
    Warachit, J
    Iwabu, Y
    Tsuji, S
    Auwanit, W
    Yamamoto, D
    Goto, T
    Hayashi, Y
    Kiso, Y
    Ikuta, K
    MICROBES AND INFECTION, 2005, 7 (03) : 356 - 364
  • [2] Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein
    De Rosny, E
    Vassell, R
    Wingfield, PT
    Wild, CT
    Weiss, CD
    JOURNAL OF VIROLOGY, 2001, 75 (18) : 8859 - 8863
  • [3] Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection
    Dehua Liu
    Hongyun Wang
    Mizuki Yamamoto
    Jiping Song
    Rui Zhang
    Qingling Du
    Yasushi Kawaguchi
    Jun-ichiro Inoue
    Zene Matsuda
    Retrovirology, 15
  • [4] Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection
    Liu, Dehua
    Wang, Hongyun
    Yamamoto, Mizuki
    Song, Jiping
    Zhang, Rui
    Du, Qingling
    Kawaguchi, Yasushi
    Inoue, Jun-ichiro
    Matsuda, Zene
    RETROVIROLOGY, 2018, 15
  • [5] A region of the C-terminal tail of the gp41 envelope glycoprotein of human immunodeficiency virus type 1 contains a neutralizing epitope: evidence for its exposure on the surface of the virion
    Cleveland, SM
    McLain, L
    Cheung, L
    Jones, TD
    Hollier, M
    Dimmock, NJ
    JOURNAL OF GENERAL VIROLOGY, 2003, 84 : 591 - 602
  • [6] An alternative conformation of the gp41 heptad repeat 1 region coiled coil exists in the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor
    Mische, CC
    Yuan, W
    Strack, B
    Craig, S
    Farzan, M
    Sodroski, J
    VIROLOGY, 2005, 338 (01) : 133 - 143
  • [7] Biophysical evidence of two docking sites of the carboxyl heptad repeat region within the amino heptad repeat region of gp41 of human immunodeficiency virus type 1
    Chang, Ding-Kwo
    Hsu, Chang-Sheng
    ANTIVIRAL RESEARCH, 2007, 74 (01) : 51 - 58
  • [8] Probing Vulnerability of the gp41 C-Terminal Heptad Repeat as Target for Miniprotein HIV Inhibitors
    Jurado, Samuel
    Moog, Christiane
    Cano-Munoz, Mario
    Schmidt, Sylvie
    Laumond, Geraldine
    Ruocco, Valentina
    Standoli, Sara
    Polo-Megias, Daniel
    Conejero-Lara, Francisco
    Morel, Bertrand
    JOURNAL OF MOLECULAR BIOLOGY, 2020, 432 (20) : 5577 - 5592
  • [9] Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition
    He, Yuxian
    Liu, Shuwen
    Li, Jingjing
    Lu, Hong
    Qi, Zhi
    Liu, Zhonghua
    Debnath, Asim K.
    Jiang, Shibo
    JOURNAL OF VIROLOGY, 2008, 82 (22) : 11129 - 11139
  • [10] Cellular membrane-binding ability of the C-terminal cytoplasmic domain of human immunodeficiency virus type 1 envelope transmembrane protein gp41
    Chen, SSL
    Lee, SF
    Wang, CT
    JOURNAL OF VIROLOGY, 2001, 75 (20) : 9925 - 9938
12345