Bottom-up tissue engineering

被引：139
|
作者：
Elbert, Donald L. [1 ,2 ]
机构：
[1] Washington Univ St Louis, Dept Biomed Engn, St Louis, MO 63130 USA
[2] Washington Univ St Louis, Ctr Mat Innovat, St Louis, MO 63130 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2011年 / 22卷 / 05期
关键词：
STEM-CELL DIFFERENTIATION; FREE CLICK CHEMISTRY; EMBRYOID BODIES; IN-VIVO; MICROTISSUES; MODULES; TRANSPLANTATION; MICROSPHERES; MICROGELS; CONSTRUCT;
D O I：
10.1016/j.copbio.2011.04.001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Recapitulating the elegant structures formed during development is an extreme synthetic and biological challenge. Great progress has been made in developing materials to support transplanted cells, yet the complexity of tissues is far beyond that found in even the most advanced scaffolds. Self-assembly is a motif used in development and a route for the production of complex materials. Self-assembly of peptides, proteins and other molecules at the nanoscale is promising, but in addition, intriguing ideas are emerging for self-assembly of micron-scale structures. In this brief review, very recent advances in the assembly of micron-scale cell aggregates and microgels will be described and discussed.
引用
收藏
页码：674 / 680
页数：7
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