The Application of Ion Mobility-Mass Spectrometry in Untargeted Metabolomics: from Separation to Identification

被引：32
|
作者：
Luo, Ming-Du [1 ,2 ]
Zhou, Zhi-Wei [1 ,2 ]
Zhu, Zheng-Jiang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai 200032, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
JOURNAL OF ANALYSIS AND TESTING | 2020年 / 4卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Ion mobility-mass spectrometry; Untargeted metabolomics; Collison cross section (CCS); Metabolite identification; Isomer separation; COLLISION CROSS-SECTION; ASSISTED-LASER-DESORPTION/IONIZATION; STRUCTURAL-CHARACTERIZATION; SYSTEMS BIOLOGY; AMINO-ACIDS; PREDICTION; VALUES; DIFFERENTIATION; METABOLITES; LIPIDOMICS;
D O I：
10.1007/s41664-020-00133-0
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Untargeted metabolomics aims to comprehensively profile metabolites as many as possible in biological samples. Recently, ion mobility-mass spectrometry (IM-MS) has emerged as a powerful technology for untargeted metabolomics. The emerging role of IM-MS in untargeted metabolomics enables the separation of metabolite isomers and generation of multidimension data to support the identification of metabolites. In this review, we first introduced the basic principles of IM-MS instruments commonly used for untargeted metabolomics. Then, we demonstrated the application of IM-MS for metabolite separation and identification of both known and unknown metabolites. Finally, we discussed the future developments of IM-MS technology to improve untargeted metabolomics.
引用
收藏
页码：163 / 174
页数：12
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