Hydrophobic core packing and protein design

被引：42

作者：

Lazar, GA ^{[1
]}

Handel, TM ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1367-5931(98)80102-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past few years, we have witnessed exciting advances in protein design. Several groups have reported success in the design of hydrophobic cores, and the principles developed in these studies have been recently applied to the full sequence design of a small protein motif and the design of a catalytically active metal center. These successes suggest that designing large, functional proteins in computero is more feasible than ever before.

引用

页码：675 / 679

页数：5

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