Synthesis and antibacterial properties of quinoxaline 1,4-dioxide derivatives

被引：15
|
作者：
Takabatake, T [1 ]
Takabatake, Y [1 ]
Miyazawa, T [1 ]
Hasegawa, M [1 ]
机构：
[1] NIHON UNIV, COLL PHARM, FUNABASHI, CHIBA 274, JAPAN
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1996年 / 116卷 / 06期
关键词：
quinoxaline 1,4-dioxide; antibacterial activity; Bacteroides fragilis; benzofuroxan;
D O I：
10.1248/yakushi1947.116.6_491
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Novel quinoxaline 1,4-dioxide derivatives were synthesized from benzo-furoxans and the enolic form of 1,3-diketones or 3-oxoalkanoic esters or 3-oxoalkanamides or butanedioic esters catalyzed by silica gel or molecular sieves and their antibacterial activities were evaluated. As the results of antibacterial screening tests in vitro, quinoxaline 1,4-dioxides revealed strong activities against Bacteroides fragilis.
引用
收藏
页码：491 / 496
页数：6
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