Development of Biocompatible Tissue-Adhesive Materials of Alginte/Poly(acrylic acid) Using Double-Network Concept

A biocompatible tissue adhesive material was prepared from alginate and poly (acrylic acid). Based on double network concept designed to improve the mechanical properties of the hydrogel, it was made in the form of a film through solution casting. The mechanical properties increased by about 1.5 times and adhesion force by about 2.4 times, depending on the crosslinking density of the primary network (alginate) and the concentration of the secondary network (poly(acrylic acid)) material. In addition, the adhesion behavior in living tissue was studied using pig lung tissue. It was shown that there was no toxicity through cytotoxicity evaluation. Through the above results, it was found that the sample had sufficient adhesive performance as a medical adhesive material.