Organocatalyst-mediated enantioselective intramolecular aldol reaction featuring the rare combination of aldehyde as nucleophile and ketone as electrophile

被引：48
|
作者：
Hayashi, Yujiro [1 ]
Sekizawa, Hiromi [1 ]
Yamaguchi, Junichiro [1 ]
Gotoh, Hiroaki [1 ]
机构：
[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 17期
关键词：
D O I：
10.1021/jo0709100
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The trifluoroacetic acid salt of 2-(pyrrolidinylmethyl)pyrrolidine was found to be an effective organocatalyst of an asymmetric intramolecular aldol reaction, affording bicyclo[4.3.0]nonane derivatives with a high enantioselectivity, in which the rare combination of aldehyde as a nucleophile and ketone as an electrophile was realized.
引用
收藏
页码：6493 / 6499
页数：7
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