Synthesis of N-1-(3,5-dimethyl-4-isoxozolyl)-3-(4-aryl-5-thioxo-4,5-dihydro-1-H-1, 2, 4-triazol-3-yl)propanamides as possible antitumor agents

被引：0

作者：

Reddy, Ch V. Narsimha ^{[2
]}

Raju, S. ^{[1
]}

Reddy, M. Nagi ^{[1
]}

Rajanarendar, E. ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

[2] LB Coll, Dept Chem, Warangal, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 12期

关键词：

Solid state reaction; acid hydrazide; aryl isothio-cyanates; isoxazolyl triazoles;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of N-1 (3, 5-dimethyl-4-isoxazolyl)-3-(4-aryl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-propanamides 7 have been accomplished from 4-amino-3,5-dimethylisoxazole 1 in five steps. The structural elucidation of the synthesized compounds has been performed by IR, H-1 NMR and mass spectroscopic data besides elemental analyses.

引用

页码：1667 / 1670

页数：4

共 50 条

[1] 3-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridinium chloride
Zhao, Guang-Qiang
Pan, Zhi-Fang
Tang, Xue-Xi
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O138 - U3734
[2] SYNTHESIS OF SOME NEW 3-(5-(ARYLAMINO)-1,3,4-THIADIAZOL-2-YL)-2H-CHROMEN-2-ONES AND 3-(4-ARYL-5-THIOXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL)-2H-CHROMEN-2-ONES
Saeed, Aamer
Ibrar, Aliya
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2011, 186 (08) : 1801 - 1810
[3] 4-(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridinium chloride
Ren, Xiao-Yan
Jian, Fang-Fang
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1792 - U2262
[4] Synthesis of 3-(3-alkyl-5-thioxo-1H-4,5-dihydro-1,2,4-triazol-4-yl)aminocarbonylchromones
Cao, LH
Zhang, L
Cui, PY
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2004, (05): : 749 - 754
[5] Synthesis of 3-(3-alkyl-5-thioxo-1H-4,5-dihydro-1,2,4-triazol-4-yl) aminocarbonylchromones
Cao L.
Zhang L.
Cui P.
Chemistry of Heterocyclic Compounds, 2004, 40 (5) : 635 - 640
[6] Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides and their tautomerism
Lim, Felicia Phei Lin
Tan, Lin Yuing
Tiekink, Edward R. T.
Dolzhenko, Anton V.
RSC ADVANCES, 2018, 8 (40): : 22351 - 22360
[7] 6-Phenyl-2-(4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin- 3(2H)-one
Mishra, Ravinesh
Siddiqui, Anees A.
Shaharyar, Mohammad
Husain, Asif
Rashid, Mohd
MOLBANK, 2010, (04)
[8] Synthesis and Antitumor Activity of Novel 1-Substituted 3-(4,5-Substituted 1,2,4-Triazol-3-yl)--carboline Derivatives
Brand, George
Gomes, Carla M. B.
Costa, Willian F.
Foglio, Mary A.
Ruiz, Ana L. T. G.
Sarragiotto, Maria H.
SYNTHESIS-STUTTGART, 2019, 51 (02): : 573 - 577
[9] 4-{3-[Hydroxy(phenyl)methyl]-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-4-yl}benzenesulfonamide
Akkurt, Mehmet
Celik, Ismail
Cihan, Goekce
Capan, Gueltaze
Buyukgungor, Orhan
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2010, 66 : O974 - U3507
[10] N-[(4-Amino-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-methylbenzamide
Fun, Hoong-Kun
Yeap, Chin Sing
Mange, Yatin
Isloor, Arun M.
Hegde, Chitrakar
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2501 - U1845

← 1 2 3 4 5 →