The role of peroxisomes in aging

被引：50
|
作者：
Périchon, R
Bourre, JM
Kelly, JF
Roth, GS
机构：
[1] NIA, Cellular & Mol Biol Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA
[2] Hop Fernand Widal, Lab Neuro Pharmaco Nutr, INSERM, U26, F-75475 Paris 10, France
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 07期
关键词：
peroxisome; aging; lipid metabolism; oxidative stress;
D O I：
10.1007/s000180050192
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Reactive oxygen species and alterations in membrane lipid homeostasis are thought to be important events in aging process and aging-related degenerative diseases. The peroxisome is a small cellular organelle involved in both oxygen and lipid metabolism, and defects in peroxisomal function are associated with major, and often fatal, changes at the neurological level during human development. Recent reports of aging-related changes in peroxisomal function raised the hypothesis that peroxisomes may also have a significant role in the aging process and aging-related degenerative diseases. This review presents the current data on changes in peroxisomal function during aging and discusses the implications of these changes for health.
引用
收藏
页码：641 / 652
页数：12
相关论文
共 50 条
  • [1] The role of peroxisomes in aging
    R. Périchon
    J. M. Bourre
    J. F. Kelly
    G. S. Roth
    Cellular and Molecular Life Sciences CMLS, 1998, 54 : 641 - 652
  • [2] Peroxisomes and aging
    Terlecky, Stanley R.
    Koepke, Jay I.
    Walton, Paul A.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2006, 1763 (12): : 1749 - 1754
  • [3] Biology of senescent liver peroxisomes: Role in hepatocellular aging and disease
    Youssef, J
    Badr, M
    ENVIRONMENTAL HEALTH PERSPECTIVES, 1999, 107 (10) : 791 - 797
  • [4] Peroxisomes, cell senescence, and rates of aging
    Giordano, Courtney R.
    Terlecky, Stanley R.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (09): : 1358 - 1362
  • [5] The impact of peroxisomes on cellular aging and death
    Manivannan, Selvambigai
    Scheckhuber, Christian Quintus
    Veenhuis, Marten
    van der Klei, Ida Johanna
    FRONTIERS IN ONCOLOGY, 2012, 2 : 1 - 7
  • [6] ROLE OF PEROXISOMES IN MAMMALIAN METABOLISM
    MANNAERTS, GP
    VANVELDHOVEN, PP
    CELL BIOCHEMISTRY AND FUNCTION, 1992, 10 (03) : 141 - 151
  • [7] Role and Function of Peroxisomes in Neuroinflammation
    Sarkar, Chinmoy
    Lipinski, Marta M.
    CELLS, 2024, 13 (19)
  • [8] THE METABOLIC ROLE OF PEROXISOMES IN TETRAHYMENA
    BLUM, JJ
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1982, 386 (MAY) : 217 - 227
  • [9] The role of peroxisomes for cholesterol homeostasis
    Kovacs, WJ
    Shackelford, J
    Tape, K
    Richards, M
    Faust, P
    Fliesler, S
    Krisans, S
    FASEB JOURNAL, 2005, 19 (05): : A1387 - A1387
  • [10] Role of peroxisomes in isoprenoid biosynthesis
    Aboushadi, N
    Engfelt, WH
    Paton, VG
    Krisans, SK
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1999, 47 (09) : 1127 - 1132
12345