The 2-13C-5-fluorouracil breath test (FUBT) as a novel, rapid method for assessment of dihydropyrimidine dehydrogenase (DPD) activity in cancer patients: Initial characterization and comparison to the 2-13C-uracil breath test (UraBT)

被引:0
|
作者
Fourie, J.
Mattison, L. K.
Wood, T. E.
Posey, J. A., III
Modak, A.
Diasio, R. B.
机构
[1] Mayo Clin, Ctr Canc, Rochester, MN USA
[2] Univ Alabama Birmingham, Birmingham, AL USA
[3] Cambridge Isotope Labs Inc, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2551
引用
收藏
页数:1
相关论文
共 25 条
  • [1] Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test
    Mattison, LK
    Ezzeldin, H
    Carpenter, M
    Modak, A
    Johnson, MR
    Diasio, RB
    CLINICAL CANCER RESEARCH, 2004, 10 (08) : 2652 - 2658
  • [2] The 2-13C-uracil breath test (UraBT) in patients with colorectal cancer:: 2-13C-uracil catabolism as a biomarker of phenotypic variability in fluoropyrimidine (FP) disposition?
    Fourie, J.
    Wood, T. E.
    Mattison, L. K.
    Posey, J. A., III
    Modak, A.
    Acosta, E. P.
    Diasio, R. B.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 : S56 - S56
  • [3] Validation of a novel [2-13C]-uracil breath test (UraBT) to detect dihydropyrimidine dehydrogenase (DPD) deficiency by LC-MS-MS analysis of [2-13C]-uracil (URA) and [2-13C]-dihydrouracil (DHU) plasma levels.
    Mattison, LK
    Johnson, MR
    Saif, W
    Modak, AS
    Hirao, Y
    Koga, T
    Shimizu, T
    Diasio, RB
    JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) : 159S - 159S
  • [4] The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity:: Pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil
    Mattison, LK
    Fourie, J
    Hirao, Y
    Koga, T
    Desmond, RA
    King, JR
    Shimizu, T
    Diasio, RB
    CLINICAL CANCER RESEARCH, 2006, 12 (02) : 549 - 555
  • [5] 13C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients
    Cunha-Junior, Geraldo Felicio
    De Marco, Luiz
    Bastos-Rodrigues, Luciana
    Bolina, Marina Borges
    Martins, Flavia Linhares
    Pianetti, Gerson Antonio
    Cesar, Isabela Costa
    Coelho, Luiz Gonzaga
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 72 (06) : 1273 - 1282
  • [6] 13C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients
    Geraldo Felício Cunha-Junior
    Luiz De Marco
    Luciana Bastos-Rodrigues
    Marina Borges Bolina
    Flavia Linhares Martins
    Gerson Antonio Pianetti
    Isabela Costa Cesar
    Luiz Gonzaga Coelho
    Cancer Chemotherapy and Pharmacology, 2013, 72 : 1273 - 1282
  • [7] 13C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients.
    Cunha, Geraldo Felicio
    de Marco, Luiz
    Bastos-Rodrigues, Luciana
    Bolina, Marina Borges
    Martins, Flavia Linhares
    Pianetti, Gerson Antonio
    Cesar, Isabela Costa
    Coelho, Luiz Gonzaga
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [8] Relationships among plasma [2-13C]uracil concentrations, breath 13CO2 expiration, and dihydropyrimidine dehydrogenase (DPD) activity in the liver in normal and DPD-deficient dogs
    Inada, M
    Hirao, Y
    Koga, T
    Itose, M
    Kunizaki, J
    Shimizu, T
    Sato, H
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (03) : 381 - 387
  • [9] Can the 2-13C-uracil breath test be used to predict the effect of the antitumor drug S-1?
    Ishii, Yukimoto
    Suzuki, Shigeru
    Takahashi, Yasuo
    Takayama, Tadatoshi
    Asai, Satoshi
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2010, 66 (02) : 333 - 343
  • [10] Can the 2-13C-uracil breath test be used to predict the effect of the antitumor drug S-1?
    Yukimoto Ishii
    Shigeru Suzuki
    Yasuo Takahashi
    Tadatoshi Takayama
    Satoshi Asai
    Cancer Chemotherapy and Pharmacology, 2010, 66 : 333 - 343