Role of Fcγ receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura

被引：52

作者：

Crow, AR

Lazarus, AH

机构：

[1] St Michaels Hosp, Dept Lab Med & Pathobiol, Toronto, ON M5B 1W8, Canada

[2] Canadian Red Cross Blood Transfus Serv, Toronto, ON, Canada

[3] Toronto Platelet Immunobiol Grp, Toronto, ON, Canada

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2003年 / 25卷

关键词：

idiopathic thrombocytopenic purpura; intravenous immunoglobulin; Fc gamma receptors; platelets; phagocytosis;

D O I：

10.1097/00043426-200312001-00004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. Platelets with associated IgG are targeted for destruction by phagocytic cells bearing Fc receptors in the reticuloendothelial system. While there are a variety of therapeutics available for this incompletely understood disease, one of the treatments of choice is infusion of intravenous immunoglobulin (IVIG). This review will discuss the pathophysiology of ITP with an emphasis on the role of Fcgamma receptors in both the pathogenesis and treatment of the disease by IVIG. Other prominent theories of the mechanisms of action of IVIG, including the role of anti-idiotype antibodies, will also be addressed.

引用

页码：S14 / S18

页数：5

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