Synthesis and insecticidal activity of novel 1,2,4-triazole derivatives containing trifluoroacetyl moieties

被引：9
|
作者：
Zhao, Fenghai [1 ]
Tang, Xianjun [1 ]
Liu, Min [1 ]
Qin, Zhaohai [1 ]
Li, Jia-Qi [1 ]
Xiao, Yumei [1 ]
机构：
[1] China Agr Univ, Dept Chem, Coll Sci, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China
来源：
MOLECULAR DIVERSITY | 2022年 / 26卷 / 04期
关键词：
1,2,4-triazole; Trifluoroacetyl; Insecticidal activity; Flupyrimin; FLUORINE;
D O I：
10.1007/s11030-021-10321-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of compounds containing trifluoroacetyl groups were synthesized, and their insecticidal activity against Nilaparvata lugens and Aphis craccivora was evaluated. The compound structure was identified by NMR, HRMS, and single-crystal diffraction. The bioassay results indicated that compound 4-1 (R-1 is chloropyridine, R-2 is H), 4-2 (R-1 is chlorothiazole, R-2 is H) and 4-19 (R-1 is benzyl, R-2 is isopropyl) had the best activity against Nilaparvata lugens (93.5%, 94.1% and 95.5%) at 100 mg/L concentration. The effect of different substituents of R-1 or R-2 on the activity was studied through the structure-activity relationship. Molecular docking of compounds 4-1 and 4-2 was discussed.
引用
收藏
页码：2149 / 2158
页数：10
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