Renewed Public Health Threat from Emerging Lyssaviruses

被引:21
|
作者
Fooks, Anthony R. [1 ]
Shipley, Rebecca [1 ]
Markotter, Wanda [2 ]
Tordo, Noel [3 ]
Freuling, Conrad M. [4 ]
Mueller, Thomas [4 ]
McElhinney, Lorraine M. [1 ]
Banyard, Ashley C. [1 ]
Rupprecht, Charles E. [5 ]
机构
[1] Who Collaborating Ctr Rabies, OIE Reference Lab Rabies, Anim & Plant Hlth Agcy APHA, Weybridge KT15 3NB, Surrey, England
[2] Univ Pretoria, Fac Hlth Sci, Ctr Viral Zoonoses, Dept Med Virol, ZA-0001 Pretoria, South Africa
[3] Inst Pasteur Guinee, Route Donka,BP 4416, Conakry, Guinea
[4] WHO Collaborating Ctr Rabies Surveillance & Res R, OIE Reference Lab, Friedrich Loeffler Inst FLI, D-17493 Greifswald, Germany
[5] LYSSA LLC, Cumming, GA 30044 USA
来源
VIRUSES-BASEL | 2021年 / 13卷 / 09期
基金
欧盟地平线“2020”;
关键词
rabies; lyssavirus; bats; emerging; novel; encephalitis; prophylaxis; zoonoses; LONG-FINGERED BATS; RABIES BIOLOGICS; IMMUNE-RESPONSES; VIRUS; VACCINE; CHIROPTERA; PHYLOGENY; EMERGENCE;
D O I
10.3390/v13091769
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Pathogen discovery contributes to our knowledge of bat-borne viruses and is linked to the heightened interest globally in bats as recognised reservoirs of zoonotic agents. The transmission of lyssaviruses from bats-to-humans, domestic animals, or other wildlife species is uncommon, but interest in these pathogens remains due to their ability to cause an acute, progressive, invariably fatal encephalitis in humans. Consequently, the detection and characterisation of bat lyssaviruses continues to expand our knowledge of their phylogroup definition, viral diversity, host species association, geographical distribution, evolution, mechanisms for perpetuation, and the potential routes of transmission. Although the opportunity for lyssavirus cross-species transmission seems rare, adaptation in a new host and the possibility of onward transmission to humans requires continued investigation. Considering the limited efficacy of available rabies biologicals it is important to further our understanding of protective immunity to minimize the threat from these pathogens to public health. Hence, in addition to increased surveillance, the development of a niche pan-lyssavirus vaccine or therapeutic biologics for post-exposure prophylaxis for use against genetically divergent lyssaviruses should be an international priority as these emerging lyssaviruses remain a concern for global public health.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Bioterrorism: A renewed public health threat
    Maddox, PJ
    NURSING ECONOMICS, 2001, 19 (06): : 286 - 290
  • [2] Public health and bioterrorism: renewed threat of anthrax and smallpox
    Wallin, Arune
    Luksiene, Zivile
    Zagminas, Kestutis
    Surkiene, Gene
    MEDICINA-LITHUANIA, 2007, 43 (04): : 278 - 284
  • [3] Obesogens: an emerging threat to public health
    Janesick, Amanda S.
    Blumberg, Bruce
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016, 214 (05) : 559 - 565
  • [4] The public health threat of emerging viral disease
    Morse, SS
    JOURNAL OF NUTRITION, 1997, 127 : S951 - S957
  • [5] Tahyna virus: an emerging threat to public health
    Zhu, Wenbing
    Shao, Lijun
    Feng, Shuo
    Lu, Ke
    Yu, Xiaoli
    Niu, Guoyu
    ARCHIVES OF VIROLOGY, 2025, 170 (03)
  • [6] INJECTIONAL ANTHRAX: AN EMERGING GLOBAL PUBLIC HEALTH THREAT
    Miller, Joseph R.
    Patrick, Shawn V.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 93 (04): : 123 - 124
  • [7] Condom as substance abuse: An emerging threat to public health
    Nayak, Biswa Prakash
    Dabas, Prashita
    Khajuria, Himanshu
    ARCHIVES OF PSYCHIATRIC NURSING, 2023, 45 : 14 - 15
  • [8] Potential arteriviral spillover: An emerging threat to public health?
    Li, Rui
    Ma, Hongfang
    Qiao, Songlin
    Zhang, Gaiping
    FRONTIERS IN MICROBIOLOGY, 2023, 14
  • [9] Acinetobacter baumannii:An emerging pathogenic threat to public health
    Suresh G Joshi
    Geetanjali M Litake
    World Journal of Clinical Infectious Diseases, 2013, (03) : 25 - 36
  • [10] Hantaviruses: an emerging public health threat in India? A review
    S. Chandy
    P. Abraham
    G. Sridharan
    Journal of Biosciences, 2008, 33 : 495 - 504