In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs

被引：39

作者：

Pradines, B

Tall, A

Fusai, T

Spiegel, A

Hienne, R

Rogier, C

Trape, JF

Le Bras, J

Parzy, D

机构：

[1] Serv Sante Armees, Inst Trop Med, Unite Parasitol, F-13998 Marseille, France

[2] Hop Bichat Claude Bernard, Ctr Natl Reference Chimiosensibil Paludisme, F-75877 Paris, France

[3] Inst Pasteur, Serv Epidemiol, Dakar, Senegal

[4] ORSTOM, Lab Paludol, Dakar, Senegal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.418

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 50% inhibitory concentration (IC(50)s) of benflumetol (range, 12.5 to 250 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.

引用

页码：418 / 420

页数：3

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