Electrochemical Sensor for Ultrasensitive Determination of Atorvastatin Based on Polypyrrole Functionalized Graphene Sheets

In this study, polypyrrole functionalized graphene sheets (PPY-GNs) have been used for the first time as a reinforced material for the ultrasensitive detection of atorvastatin by the electrochemistry method. The obtained PPY-GNs were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectroscopy. Due toits porous structure, the PPY-GNs- modified electrode has a large effective area, thereby improving the sensitivity of detection. The peak currents of atorvastatin at the GNs-modified glassy carbon electrode (GNs/GCE) and those at the PPY-GNs/GCE are increased dramatically compared to those on the bare GCE. The peak current at the PPY-GNs/GCE linearly increases with the increase in the atorvastatin concentration, which ranges from 20 mu M to 200 mu M. The detection limit of atorvastatin reaches 1.191 mu M based on the signal-to-noise characteristic (S/N = 3). The PPY-GNs-based electrochemical sensor was successfully used to detect atorvastatin in tablets with satisfactory results.