Pterocarpenes elicited by Aspergillus caelatus in peanut (Arachis hypogaea) seeds

The substituted pterocarpenes named aracarpene-1 (1) and aracarpene-2 (2) were isolated from wounded peanut seeds challenged by a strain of Aspergillus caelatus The structures of these putative phytoalexins were determined by interpretation of NMR and MS data The aracarpenes were investigated for their antifungal and antibacterial activities as well as antioxidant anti-inflammatory and cytotoxic activities in mammalian cells Aracarpene-2 demonstrated high antibacterial properties against tested gram-positive and gram-negative bacteria whereas aracarpene-1 displayed low antibacterial properties against the same bacteria Both compounds had no antifungal activity against Aspergillus flavus Together with peanut stilbenoids that are also produced in the challenged seeds these compounds may represent a class of low-molecular weight peanut metabolites with a defensive role(s) against pathogenic microorganisms Published by Elsevier Ltd