New bicyclic taxane diterpenoids from Taxus sumatrana

被引：15

作者：

Shen, YC

Hsu, SM

Lin, YS

Cheng, KC

Chien, CT

Chou, CH

Cheng, YB

机构：

[1] Natl Sun Yat Sen Univ, Inst Marine Resources, Kaohsiung 80424, Taiwan

[2] Taiwan Forestry Res Inst, Div Silviculture, Taipei, Taiwan

[3] Natl Pingtung Univ Sci & Technol, Pingtung 912, Taiwan

[4] Natl Sun Yat Sen Univ, Inst Biol, Kaohsiung, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 07期

关键词：

Taxaceae; Taxus sumatrana; taxane diterpene;

D O I：

10.1248/cpb.53.808

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of an acetone extract of the leaves and twigs of, Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2 alpha,7 beta,13 alpha-triacetoxy-5 alpha,9 alpha-dihydroxy-2(3 -> 20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization.

引用

页码：808 / 810

页数：3