Lifestyle associated factors and risk of urinary bladder cancer: A prospective cohort study from Norway

被引:7
|
作者
Hektoen, Helga H. [1 ]
Robsahm, Trude E. [1 ]
Andreassen, Bettina K. [1 ]
Stenehjem, Jo S. [1 ,2 ]
Axcrona, Karol [3 ]
Mondul, Alison [4 ]
Gislefoss, Randi E. [1 ]
机构
[1] Canc Registry Norway, Dept Res, Oslo, Norway
[2] Univ Oslo, Dept Biostat, Oslo Ctr Biostat & Epidemiol, Oslo, Norway
[3] Akershus Univ Hosp, Dept Urol, Lorenskog, Norway
[4] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA
来源
CANCER MEDICINE | 2020年 / 9卷 / 12期
关键词
body mass index; cohort study; metabolic syndrome; physical activity; urinary bladder cancer; BODY-MASS INDEX; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; DIABETES-MELLITUS; SMOKING; HYPERTENSION; OBESITY; MORTALITY; MEN; EPIDEMIOLOGY;
D O I
10.1002/cam4.3060
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A number of lifestyle associated factors, such as high body mass index (BMI), low physical activity, and related metabolic disorders, are associated with increased risk of cancer at several sites. For urinary bladder cancer (BC), such studies show inconsistent results, which could result from inadequate adjustment for smoking and occupational exposure. In the population-based Janus Cohort (n = 292 851), we investigated the independent and combined impact of BMI, physical activity, blood pressure, and blood lipids on the risk of BC, by thorough adjustment for smoking and potential occupational exposure. We used cox proportional hazard regression to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for the associations between the lifestyle associated factors and BC risk. The associations observed were dependent on smoking status and gender. Among men, diastolic blood pressure (DBP) (HR 1.07, 95% CI 1.02-1.12) and systolic blood pressure (SBP) (HR 1.04, 95% CI 1.01-1.07) were positively associated with BC risk. Stratification by smoking status revealed a positive association between DBP and BC risk in never smokers (HR 1.14, 95% CI 1.00-1.30), while no association was seen for current and former smokers. A risk score, integrating information across the lifestyle factors was positively associated with BC risk in men (p(trend) = 0.043). In women, physical activity was associated with a decreased BC risk, but only among never smokers (HR 0.65, 95% CI 0.45-0.94). In conclusion, relations between lifestyle associated factors and BC risk were most evident in never smokers, suggesting that smoking dominates the relation in current smokers.
引用
收藏
页码:4420 / 4432
页数:13
相关论文
共 50 条
  • [1] A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trondelag, Norway
    Nilsen, TIL
    Vatten, LJ
    CANCER CAUSES & CONTROL, 2000, 11 (07) : 645 - 652
  • [2] A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trøndelag, Norway
    Tom I. Lund Nilsen
    Lars J. Vatten
    Cancer Causes & Control, 2000, 11 : 645 - 652
  • [3] Composite Score of Healthy Lifestyle Factors and the Risk of Pancreatic Cancer in a Prospective Cohort Study
    Luu, Hung N.
    Paragomi, Pedram
    Wang, Renwei
    Jin, Aizhen
    Brand, Randall E.
    Koh, Woon-Puay
    Yuan, Jian-Min
    CANCER PREVENTION RESEARCH, 2022, 15 (01) : 29 - 36
  • [4] COMPOSITE SCORE OF HEALTHY LIFESTYLE FACTORS AND RISK OF PANCREATIC CANCER IN A PROSPECTIVE COHORT STUDY
    Luu, Hung N.
    Paragomi, Pedram
    Wang, Renwei
    Jin, Aizhen
    Brand, Randall
    Koh, Woon-Puay
    Yuan, Jian-Min
    GASTROENTEROLOGY, 2021, 160 (06) : S474 - S474
  • [5] Lifestyle and metabolic factors affect risk for meningioma in women: a prospective population-based study (The Cohort of Norway)
    Gheorghiu, Anamaria
    Brunborg, Cathrine
    Johannesen, Tom B.
    Helseth, Eirik
    Zwart, John-Anker
    Wiedmann, Markus K. H.
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [6] Awareness of risk factors and fallacies associated with urinary bladder cancer in our population: A prospective survey
    Mithani, Muhammad Hammad
    Khan, Shariq Anis
    El Khalid, Salman
    Siddique, Rakhshanda
    Humayun, Hafsa
    Awan, Adnan Siddiq
    JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2018, 68 (01) : 55 - 58
  • [7] Lifestyle Factors and Risk of Restless Legs Syndrome: Prospective Cohort Study
    Batool-Anwar, Salma
    Li, Yanping
    De Vito, Katerina
    Malhotra, Atul
    Winkelman, John
    Gao, Xiang
    JOURNAL OF CLINICAL SLEEP MEDICINE, 2016, 12 (02): : 187 - 194
  • [8] The Be-Well Study: a prospective cohort study of lifestyle and genetic factors to reduce the risk of recurrence and progression of non-muscle-invasive bladder cancer
    Kwan, Marilyn L.
    Kushi, Lawrence H.
    Danforth, Kim N.
    Roh, Janise M.
    Ergas, Isaac J.
    Lee, Valerie S.
    Cannavale, Kimberly L.
    Harrison, Teresa N.
    Contreras, Richard
    Loo, Ronald K.
    Aaronson, David S.
    Quesenberry, Charles P.
    Tritchler, David
    Ghai, Nirupa R.
    Quinn, Virginia P.
    Ambrosone, Christine B.
    Zhang, Yuesheng
    Tang, Li
    CANCER CAUSES & CONTROL, 2019, 30 (02) : 187 - 193
  • [9] The Be-Well Study: a prospective cohort study of lifestyle and genetic factors to reduce the risk of recurrence and progression of non-muscle-invasive bladder cancer
    Marilyn L. Kwan
    Lawrence H. Kushi
    Kim N. Danforth
    Janise M. Roh
    Isaac J. Ergas
    Valerie S. Lee
    Kimberly L. Cannavale
    Teresa N. Harrison
    Richard Contreras
    Ronald K. Loo
    David S. Aaronson
    Charles P. Quesenberry
    David Tritchler
    Nirupa R. Ghai
    Virginia P. Quinn
    Christine B. Ambrosone
    Yuesheng Zhang
    Li Tang
    Cancer Causes & Control, 2019, 30 : 187 - 193
  • [10] Association of outdoor air pollution, lifestyle, genetic factors with the risk of lung cancer: A prospective cohort study
    Liang, Huaying
    Zhou, Xin
    Zhu, Yiqun
    Li, Dianwu
    Jing, Danrong
    Su, Xiaoli
    Pan, Pinhua
    Liu, Hong
    Zhang, Yan
    ENVIRONMENTAL RESEARCH, 2023, 218