Perspectives of glycemic variability in diabetic neuropathy: a comprehensive review

被引:22
|
作者
Zhang, Xiaochun [1 ]
Yang, Xue [2 ]
Sun, Bao [3 ,4 ]
Zhu, Chunsheng [1 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[2] Chinese Acad Sci, CAS Key Lab Separatin Sci Analyt Chem, Natl Chromatog Res & Anal Ctr, Dalian Inst Chem Phys, Dalian 116000, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410000, Peoples R China
[4] Cent South Univ, Inst Clin Pharmacol, Changsha 410000, Peoples R China
基金
中国国家自然科学基金;
关键词
CARDIOVASCULAR AUTONOMIC NEUROPATHY; CELL TRANSPLANTATION THERAPY; BLOOD-GLUCOSE VARIABILITY; CORONARY-ARTERY-DISEASE; FASTING PLASMA-GLUCOSE; TO-TARGET TRIAL; PERIPHERAL NEUROPATHY; INSULIN DEGLUDEC; HBA1C VARIABILITY; OPEN-LABEL;
D O I
10.1038/s42003-021-02896-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Zhang et al. describe metrics for evaluating glycaemic variability (GV) in clinical practice and summarize the role and related mechanisms of GV in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. They aim to stimulate ideas for the treatment of diabetic neuropathy. Diabetic neuropathy is one of the most prevalent chronic complications of diabetes, and up to half of diabetic patients will develop diabetic neuropathy during their disease course. Notably, emerging evidence suggests that glycemic variability is associated with the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for diabetic neuropathy. In this review, we describe the commonly used metrics for evaluating glycemic variability in clinical practice and summarize the role and related mechanisms of glycemic variability in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. In addition, we also address the potential pharmacological and non-pharmacological treatment methods for diabetic neuropathy, aiming to provide ideas for the treatment of diabetic neuropathy.
引用
收藏
页数:9
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