Enantioselective substitution of N-acylated α-amino acids by electrochemical oxidation

被引：15

作者：

Matsumura, Y ^{[1
]}

Wanyoike, GN ^{[1
]}

Onomura, O ^{[1
]}

Maki, T ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmaceut Sci, Nagasaki 8528521, Japan

来源：

ELECTROCHIMICA ACTA | 2003年 / 48卷 / 20-22期

关键词：

enantioselective substitution; N-acylated alpha-amino acids; electrochemical oxidation;

D O I：

10.1016/S0013-4686(03)00361-X

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Electrochemical oxidation of optically active N-acylated alpha-amino acids gave N,O-acetals with enantioselectivity of up to 83% ee. The nature of the protecting groups, reaction conditions, and the materials for anode were found to affect the enantioselectivity. The mechanistic aspect of this electrochemical oxidation was also investigated. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2957 / 2966

页数：10

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