Effects of a New Benzimidazole Derivative with Actoprotective Properties on Spermatogenic Epithelium of the Testes and Fertility of Male White Rats

被引:0
|
作者
Bugaeva, L., I [1 ]
Kuzubova, E. A. [1 ]
Petrov, V., I [1 ]
Kataev, V. A. [1 ]
Kharlamov, I., V [1 ]
Mal'tsev, M., V [1 ]
Lavrova, E. B. [1 ]
机构
[1] Volgograd State Med Univ, Res Ctr Innovat Med Subst, Minist Hlth Russian Federat, Volgograd, Russia
关键词
benzimidazole derivative; reproductive function; spermatogenesis; fertilizing ability; actoprotective substances;
D O I
10.1007/s10517-020-04823-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The effects of a new derivative of benzimidazole (K-134) in doses of 5 and 50 mg/kg on the spermatogenesis and fertilizing ability of spermatozoa were studied on male rats. It was found that 2-month course treatment with the studied substance enhances the producing ability of the spermatogenic epithelium and improves fertilizing ability of spermatozoa.
引用
收藏
页码:57 / 59
页数:3
相关论文
共 12 条
  • [1] Effects of a New Benzimidazole Derivative with Actoprotective Properties on Spermatogenic Epithelium of the Testes and Fertility of Male White Rats
    L. I. Bugaeva
    E. A. Kuzubova
    V. I. Petrov
    V. A. Kataev
    I. V. Kharlamov
    M. V. Mal’tsev
    E. B. Lavrova
    Bulletin of Experimental Biology and Medicine, 2020, 169 : 57 - 59
  • [2] EFFECTS OF REPEATED TEMPERATURE APPLICATIONS TO TESTES ON FERTILITY IN MALE RATS
    BOWLER, K
    JOURNAL OF REPRODUCTION AND FERTILITY, 1967, 14 (01): : 171 - &
  • [3] Effects of a New Benzimidazole Derivative on Generative Function of Female Rats
    E. A. Kuzubova
    L. I. Bugaeva
    S. A. Sergeeva
    V. I. Petrov
    V. A. Kataev
    I. V. Kharlamov
    M. V. Mal’tsev
    Bulletin of Experimental Biology and Medicine, 2015, 159 : 635 - 637
  • [4] Effects of a New Benzimidazole Derivative on Generative Function of Female Rats
    Kuzubova, E. A.
    Bugaeva, L. I.
    Sergeeva, S. A.
    Petrov, V. I.
    Kataev, V. A.
    Kharlamov, I. V.
    Mal'tsev, M. V.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2015, 159 (05) : 635 - 637
  • [5] EFFECTS OF ANTITUBERCULAR AGENTS CO-ADMINISTRATION ON THE EXPRESSION OF CYTOCHROME P450 ISOFORMS AND SPERMATOGENIC EPITHELIUM STATE IN RATS TESTES
    Shayakhmetova, Ganna
    Bondarenko, L.
    Matvienko, A.
    Kovalenko, V.
    DRUG METABOLISM REVIEWS, 2012, 44 : 111 - 111
  • [6] Effects of electromagnetic field on testes and semen characteristics in male New Zealand white rabbits
    Yildiz-Gulay, Ozlem
    Gulay, Mehmet Sukru
    Ata, Ayhan
    Balic, Ahsev
    INDIAN JOURNAL OF ANIMAL RESEARCH, 2017, 51 (04) : 665 - 669
  • [7] EFFECTS OF NEW MULTI-SITE HORMONE BLOCKERS AND FERTILITY OF MALE RATS
    GOLDMAN, AS
    SHAPIRO, BH
    ROOT, AW
    JOURNAL OF ENDOCRINOLOGY, 1976, 69 (01) : 11 - 21
  • [8] EFFECTS OF A NEW BENZIMIDAZOLE DERIVATIVE, NC-1300-O-3, ON GASTRIC-SECRETION AND GASTRODUODENAL LESIONS IN RATS
    OKABE, S
    AKIMOTO, Y
    YAMASAKI, S
    KUWAHARA, K
    JAPANESE JOURNAL OF PHARMACOLOGY, 1991, 55 (04): : 477 - 491
  • [9] Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets
    Asaka, Naomasa
    Kakuo, Hiroyuki
    Ohmori, Kouichi
    Sasaki, Eiji
    Togawa, Michinori
    Yamada, Shozo
    Oka, Tatsuzo
    Kiniwa, Mamoru
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2010, 60 (09): : 564 - 570
  • [10] A NEW NONHORMONAL ANTIFERTILITY DRUG DL111-IT - .1. EFFECTS ON TESTES AND ACCESSORY-GLANDS OF REPRODUCTION IN MALE-RATS
    PRASAD, RS
    VIJAYAN, E
    CONTRACEPTION, 1986, 33 (01) : 79 - 88